Effects of Salvianolic Acid B Injection on Hemodynamic Ariables in Anaesthetized Open-chest Dogs in Vivo

OBJECTIVE To investigate hemodynamic ariables in anaesthetized open-chest dogs after the intravenous injection of salvianolic acid B. METHODS The hemodynamic ariables of open-chest dogs were observed after intravenous injection of salvianolic acid B (SAL-B) at doses of 0.8, 1.6, 3.2 mg·kg-1. RESULTS 3.2 mg·kg-1 SAL-B had the potency of decreasing the DAP, MAP, and HR of the experimental dogs in first 30 minutes, 3.2 mg·kg-1 of SAL-B significantly increased CBF and decreased LVEDP of the experimental dogs. And these test results in experimental group were significantly different from those in control group at some time points. CONCLUSIONS SAL-B has effect of improving cardiac function, which indicates SAL-B has a well perspective of clinical value.