Preparation of Breviscapine Oral Disintegrating Tablets

OBJECTIVE Breviscapine was used as the model drug to develop oral disintegrating tablets. METHODS The formulation and preparation process of breviscapine orally disintegrating tablets optimized by single factor experiment using sedimentation volume and disintegration time as the main evaluation parameter. RESULTS Breviscapine orally disintegrating tablets were prepared by lyopyilization, containing the inactive ingredient: mannitol, gelatin, xanthan gum, aspartame and field-mint. The prepared tablets tasted fine and could disintegrate in 4 s. The in vitro dissolution test indicated that 98.72% of breviscapine dissolved in 4 minutes from the oral disintegrating tablets. CONCLUSION The prepared breviscapine oral disintegrating tablets disintegrates rapidly in oral cavity. The process of preparation is feasible.