Factors Influencing the Release of Potassium Citrate Gel Matrix Sustained-release Pill in Vitro

OBJECTIVE To investigate the formulated and technological factors that influence the release of potassium citrate gel matrix sustained-release pill. METHODS The factors which include different models and different viscosity of HPMC, the size of pills and production pressure were investigated by determining the content of postassium citrate in potassium citrate solution using the UV spectrophortometry. RESULTS The release of sustained-release pills in vitro was in line with of the requirements of USP for the potassium citrate extended-release tablets. CONCLUSION The formulations can be used as alternative formulations for the treatment of related diseases.