The Influence of Akebiae Extract on the Formation of Venous Thrombosis in Rats

OBJECTIVE To study the influence of akebiae extract on the formation of venous thrombosis in rats and offer experiment basis to cure venous thrombosis. METHODS Copy the rat model of venous thrombosis associated with oral administration of akebiae extract(100, 200 mg·kg-1). At the same time, there are two other groups: model group(given 0.9% NaCl), positive contrast group(given warfarin sodium). At the end of the experiment, the thrombus wet weight and thrombus dry weight of the rats were measured and the inhibitory rates in the formation of venous thrombosis were calculated. RESULTS Compared with the model group, the thrombus wet weight and dry weight of rats given 100 mg·kg-1 of akebiae extract showed only a trend of reduction, while 200 mg·kg-1 of akebiae extract had the remarkable effect of resisting the thrombus formation. And the inhibitory rates of wet weight were 19.9% and 48.6% , the inhibitory rates of dry weight were 15.5% and 42.8%, respectively. CONCLUTION Akebiae extract could significantly inhibit the formation of venous thrombosis in rats.