Research of Intervention of Angiotensin-Converting Enzyme Inhibitors to the Cytokines in the Patients with Heart Failure

Congestive heart failure (CHF) is a clinical syndrome caused by a variety of cardiovascular diseases. Its pathophysiological mechanism is not only the activation of sympathetic nervous system (SNS) and rennin-angiotensin-aldosterone system (RAAS), but also the activation and imbalance of cytokine in the development of CHF. Angiotensin converting enzyme inhibiter (ACEI) have been shown to block the activation of this system, reverse myocardial hypertrophy, as well as to prevent and delay the LV remodeling, delay and prevent the progress of CHF. This paper summarizes the status research of the intervention of ACEI to the inflammatory cytokines in the patients with CHF, and explores the effects of CHF through this way.