Effect of Bifendate Dripping Bills on Liver Fibrosis Markers in Blood Serum and Liver Histopathology

OBJECTIVE To evaluate the effect of bifendate dripping pills on liver fibrosis markers in blood serum, such as Hyalurnic Acid(HA), laminin(LN), type-Ⅳ collagen protein(Ⅳ-CP)，type-Ⅲ procollagen(PCⅢ), and liver histopathological changes. METHODS 178 patients with chronic moderate viral hepatitis B divides into the treatment group and the control group randomly. The levels of these liver fibrosis markers in blood serum were detected by radioimmunoassay before and after therapy. Liver biopsy was taken to detect the inflammation and fibrosis degree change. RESULTS Bifendate dripping pills can significantly decrease the level of liver fibrosis markers in blood serum. Bifendate dripping pills can significantly degrade the liver pathological inflammation grades, while no significant influence on the pathological fibrosis stages. CONCLUSION Bifendate dripping pills can improve the liver fibrosis markers in blood serum. But it cannot significantly improve the liver histopathological fibrosis.