Study on Sterility Test of Pefloxacin Mesylate for Injection

OBJECTIVE To verify the sterility test of pefloxacin mesylate for injection. METHODS Make sure of the best neutralizer dose added into the culture medium at the same time of comparing the membrane filtration method with the method of adding the neutralizer into the culture medium. RESULTS The method of adding 0.5 mol · L-1 of manganese sulfate solution as neutralizer into the culture medium was better than the membrane filtration method, and the best dose was 3 mL. CONCLUSION The method of adding the neutralizer into the culture medium reduces the flushing dose effectively and can be used in the sterility test of pefloxacin mesylate for injection.