Selection of Phase-transition Temperature and Preparation of Polysaccharide Thermosensitive Gel for External Application

OBJECTIVE To develop a method for formula selection of polysaccharide thermosensitive gel for external application，which was carried out in the study. METHODS Prunella vulgaris polysaccharide thermosensitive gel was mainly prepared with poloxamer by screening prescription with the curve of lgt(phase-transition time)-T(phase-transition temperature),which was developed by investigating the relationship of T and t at a certain environment temperature. RESULTS It showed that P407/P188（17%/1%）, the phase-transition temperature and time of which were 29-30 ℃ and 30-60 s，respectively. CONCLUSION It meets the requirements of polysaccharide thermosensitive gel for external application. Actually it also provides a referred selection method for preparations of this kind.