Antibody Directed Enzyme Prodrug Therapy

OBJECTIVE This review presents the background and the development of antibody-directed enzyme prodrug therapy(ADEPT), and evaluates the application potential of the technology. METHODS This review analyzes and summarizes the related literatures in recent years. RESULTS ADEPT is a novel therapeutic approach that targets an enzyme into tumors to convert a relatively nontoxic prodrug into an active cytotoxic agent. This method has a number of advantages, including the reduction of systemic toxicity. CONCLUSION ADEPT is a promosing technique for the cancer target therapy.