Analysis of the Irrational Drug Use of Intravenous Antineoplastic Agents

OBJECTIVE To enhance the rational drug use of intravenous antineoplastic agents.METHODSRetrospective statistical analysis of irrational drug use of antineoplastic agents, detected by pharmacists during prescription check in Center for Pharmacy Intravenous Admixture Services (PIVAS), were conducted. RESULTSThe main problems were as follows: selection of irrational dilution solution (about 51%), incorrect implementation of doctors′ orders by nurses (about 18%), inappropriate medication route (about 15%), absence of pharmacoeconomic considerations (about 9%) and irrational dosage regimens (about 7%). The modification rate of irrational prescriptions reached more than 98% after clinical interventions by pharmacist. CONCLUSIONPharmacists in PIVAS can play pivotal roles in rational use of intravenous antineoplastic agents. It is essential to further improve the ability of pharmacist in prescription check, conduct medication education to nurses, establish guidelines for rational drug use and strengthen communications among medical staff.