Study on Stability of Azlocillin Sodium For Injection in 5% Xylitol Injection

OBJECTIVE To study the stability of azlocillin sodium in 5% xylitol injection.METHODSThe content of azlocillin sodium was determined by HPLC and the effect of temperature on the stability of azlocillin sodium in 5% xylitol injection was detected by classic isothermal accelerated tests and multiple linear model. RESULTSThere was a linearity between the azlocillin contents in the 5% xylitol injection in logarithm (lgC) and time (t) at each temperature.It responded to the first order kinetic reaction. The expiration dates of azlocillin sodium 5% xylitol injection detected by classic isothermal accelerated tests and multiple linear model were 5.09 days and 5.59 days, respectively.CONCLUSIONIts expiration dates are the same calculated by 2 different methods. Azlocillin sodium in 5% xylitol injection was stable within 5d at room temperature (25 ℃).