The Synthesis of Garenoxacin

OBJECTIVE To prove synthetic procedure of Garenoxacin.METHODSGarenoxacin was synthesized from 1R-methyl -5-Bromo-1H-isoindole via N-alkylation, boronation, condensation and deprotection. RESULTSGarenoxacin was prepared in an overall yield of 51.0%.The structure of the target compound was confirmed by IR spectra, MS, H-NMR and elemental analysis. CONCLUSIONThe procedure avoids the use of expensive reagents and the target compound was synthesized in a few steps, so it benefits to the production of industry.