Studies on the Optimizing Condition of Risperdione Microsphere in Vitro Release by RSM

OBJECTIVE To optimize the conditions of the microsphere release in vitro rapidlly.METHODS To prepare biodegradable risperdione microsphere, the method of Box-Benhnke design and the Response Surface Analysis were used to optimize the experiment conditions of risperdione microsphere accelerating release in vitro.RESULTS The conditions of accelerating release in vitro were optimized: temperature 48 ℃，phosphate buffered saline pH 4.62，concentration of solvent is 24%.The experiment indicated that the optimum parameters were satisfactory.CONCLUSION The optimized accelerating release in vitro and long-term release were well correlated.