Optimization of Volatile Oils Extraction and β-cyclodextrin Inclusion from Piyanjing Granules

OBJECTIVE To specify optimize condition of process for mixture extraction of volatile oils and preparation of β-CD inclusion compound of Piyanjing granules．METHODS Taking weight of volatile oils to evaluate the extraction process and percentage recovery of inclusion compound,transfer rate of oils to evaluate the inclusion process．Orthogonal design was applied．RESULTS The optimum extraction condition was to add eight times amount of water into the mixture of crude drugs，to soak for 1 h，to heat up to boiling and reflux 8 h.The optimum inclusion condition was volatile oils: β-CD in proportion as 1∶6 was mixed, the inclusion temperature was at 40 ℃ and inclusion time was 3 h.CONCLUSION Above condition of process was the most rational in extraction and inclusion of Piyanjing granules.