Improved Synthesis of Clofarabine

OBJECTIVE To synthesize the title compound and improve the process. METHODS 3,5-di-O-benzoyl-2-deoxy-2-fluoro-α-D-arabinofuranosyl chloride (compound6) was synthesizes from 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose.clofarabine was obtained by the reaction of the compound 6 and 2-chloroadenine in the presence of SnCl4. RESULTS The total yield was up to 8.4%.The target compound was identified by IR，1H-NMR and MS. CONCLUSION The improved process is simple and easy for a scale production.