Effects of Arecoline on Proliferation,Apoptosis and Inflammation Response of Cells

OBJECTIVE and METHODS To review and introduce the research progress of the effect of arecoline and its derivative on cell proliferation and apoptosis.METHODS and CONCLUSION Through the action of nitrosamine and reactive oxygen species,arecoline and its derivative attack multiple target of cell to finally generate systemic toxicity resulting in inhibiting cell proliferation, inducing the cell cycle arrest and cell apoptosis. Arecoline and its derivative could influence the function of immune system with regulating the expression of the important cytokines and resulting in inflammation response. If some groups of arecoline′s structure were modified,its biology action would be changed and the arecoline derivatives were possible to be developed to be the anti-tumour drugs.