The Effects on Anti-depression of Centella Triterpenic Genine

OBJECTIVE To investigate the anti-depressed effects of Centella triterpenic genines and to explore its possible mechanism.METHODS Rat force-swim model test were used to observe the effect of Centella triterpenic genines on relieving depression. The mechanism was examined by inhibiting reuptake of monoamine neurotransmitters.RESULTS Centella triterpenic genines dramatically reduced the immobility time in the forced swim test of rats. Centella triterpenic genines had no obvious inhibition from reuptake of monoamine neurotransmitters of noradrenalin and dopamine, but could distinctly increased the frequency of head-twitch in the 5-hydroxytryptophan (5-HTP) induced head-twitches test．CONCLUSION Centella triterpenic genines has antidepressant effects,and its mechanism may be related to the reinforcement of 5-hydroxytrypamine(5-HT)nerves system．