A Study on the Process of the Butyl Rubber Stopper of Infusion Bottle

OBJECTIVE The influence of the butyl rubber bottle stopper on insoluble particles in solution by different processing methods was discussed. METHODS Filtered purification water washing, ultrasonic wave washing, boiling water washing and acid and alkali processing method are used to wash butyl rubber bottle stopper and then sterilized by 115 ℃ high pressure steam for 30 minutes. Then the visible foreign bodies and the number of insoluble particles were checked. RESULTS The solution in the bottles disposed by acid and alkali processing had the least visible foreign bodies and insoluble particles comparing with other methods. CONCLUSION Acid and alkali processing is an ideal method, and ultrasonic wave washing is another useful alternative.