CHEN Zhi-wei, YAN Wei-hua, SU Wei-ke. Synthesis of 3-(2′-Chloro-6′-fluorophenyl)-5-methylisoxazole-4-carbonyl Chloride[J]. Chinese Journal of Modern Applied Pharmacy, 2008, (4): 308-309.
Citation:
CHEN Zhi-wei, YAN Wei-hua, SU Wei-ke. Synthesis of 3-(2′-Chloro-6′-fluorophenyl)-5-methylisoxazole-4-carbonyl Chloride[J]. Chinese Journal of Modern Applied Pharmacy, 2008, (4): 308-309.
CHEN Zhi-wei, YAN Wei-hua, SU Wei-ke. Synthesis of 3-(2′-Chloro-6′-fluorophenyl)-5-methylisoxazole-4-carbonyl Chloride[J]. Chinese Journal of Modern Applied Pharmacy, 2008, (4): 308-309.
Citation:
CHEN Zhi-wei, YAN Wei-hua, SU Wei-ke. Synthesis of 3-(2′-Chloro-6′-fluorophenyl)-5-methylisoxazole-4-carbonyl Chloride[J]. Chinese Journal of Modern Applied Pharmacy, 2008, (4): 308-309.
Synthesis of 3-(2′-Chloro-6′-fluorophenyl)-5-methylisoxazole-4-carbonyl Chloride
OBJECTIVE To study the synthetic method of 3-(2-Chloro-6-fluoro phenyl)-5-methylisoxazole-4-carbonyl chloride.METHODS The objective compound was synthesized by steps of oximation,chlorination,cyclization,hydrolysis,acyl chlorination,starting from 2-chloro
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