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    ZHU Di-feng, WU Hong-hai, WU Guo-lan, LOU Jian-shu, HE Qiao-jun, YANG Bo. Determination of Ropivacaine in Guinea Pig Plasma after Infiltration Anaesthesia by Liquid Chromatography-tandem Mass Spectrometry[J]. Chinese Journal of Modern Applied Pharmacy, 2008, (3): 183-186.
    Citation: ZHU Di-feng, WU Hong-hai, WU Guo-lan, LOU Jian-shu, HE Qiao-jun, YANG Bo. Determination of Ropivacaine in Guinea Pig Plasma after Infiltration Anaesthesia by Liquid Chromatography-tandem Mass Spectrometry[J]. Chinese Journal of Modern Applied Pharmacy, 2008, (3): 183-186.
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    Determination of Ropivacaine in Guinea Pig Plasma after Infiltration Anaesthesia by Liquid Chromatography-tandem Mass Spectrometry

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    • OBJECTIVE To develop a sensitive and selective LC-MS/MS method for the determination of ropivacaine and pharmacokinetics in guinea pig plasma.METHODS After a simple sample preparation procedure by one-step protein precipitation with acetonitrile,the HPLC
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