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    CHAI Yu-zhu, CHENG Guo-hua, WANG Li, FAN Lin. Synthesis of Antidepressant Drug Duloxetine Hydrochloride[J]. Chinese Journal of Modern Applied Pharmacy, 2007, (3): 209-211.
    Citation: CHAI Yu-zhu, CHENG Guo-hua, WANG Li, FAN Lin. Synthesis of Antidepressant Drug Duloxetine Hydrochloride[J]. Chinese Journal of Modern Applied Pharmacy, 2007, (3): 209-211.
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    Synthesis of Antidepressant Drug Duloxetine Hydrochloride

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    • OBJECTIVE To synthesize duloxetine hydrochloride and optimize the process.METHODS Duloxetine hydrochloride was synthesized by steps of reaction(Mannich reaction,reduction,separation,etherication,demethylation and salification) from 2-acetylthiophene. RESU
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