Synthesis of lobaplatin

FENG Xiu-zheng, ZHANG Feng, XU Yu-li, ZHOU Zhi-hong. Synthesis of lobaplatin[J]. Chinese Journal of Modern Applied Pharmacy, 2006, (6): 465-466.

Citation:

FENG Xiu-zheng, ZHANG Feng, XU Yu-li, ZHOU Zhi-hong. Synthesis of lobaplatin[J]. Chinese Journal of Modern Applied Pharmacy, 2006, (6): 465-466.

Citation:

FENG Xiu-zheng, ZHANG Feng, XU Yu-li, ZHOU Zhi-hong. Synthesis of lobaplatin[J]. Chinese Journal of Modern Applied Pharmacy, 2006, (6): 465-466.

Abstract

OBJECTIVE To synthesze lobaplatin and optimize the process.METHODS The compound was synthesize by steps of reduction,condensation and cyclic condensation from 1,2-dicyanocyclobutane. RESULTS Chemical structure of the product was confirmed by melting point

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