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    DAI Hou-ling, CHEN Yu-bin. Synthesis of pemetrexed[J]. Chinese Journal of Modern Applied Pharmacy, 2006, (6): 459-461.
    Citation: DAI Hou-ling, CHEN Yu-bin. Synthesis of pemetrexed[J]. Chinese Journal of Modern Applied Pharmacy, 2006, (6): 459-461.
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    Synthesis of pemetrexed

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    • OBJECTIVE To study the synthesis of pemetrexed.METHODS Pemetrexed was synthesized starting from p-iodobenzoic acid via ten steps,including chlorination,esterification,condensation,cyclization,hydrolysis and saponification. RESULTS The structure of the tar
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