Synthesis of entacapone

XIONG Yuan-zhen, WU Shu-fang, ZHOU Nan-jin. Synthesis of entacapone[J]. Chinese Journal of Modern Applied Pharmacy, 2005, (6): 456-456.

Citation:

XIONG Yuan-zhen, WU Shu-fang, ZHOU Nan-jin. Synthesis of entacapone[J]. Chinese Journal of Modern Applied Pharmacy, 2005, (6): 456-456.

Citation:

XIONG Yuan-zhen, WU Shu-fang, ZHOU Nan-jin. Synthesis of entacapone[J]. Chinese Journal of Modern Applied Pharmacy, 2005, (6): 456-456.

Abstract

OBJECTIVE In order to increase product rate,new way has been taken to prepare and purify entacapone.METHOD 3,4-dihydroxy-5-nitro-benzaldehyde was used to react with N,N-diethylcyanoacetamide,between which taking place knoevengal reaction in base condition

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