ZHANG Shi-ying, LIU Hong, WANG Jie, WU Da-jun. Synthesis of 3-[4-(methylsulfonyl)phenyl]-2-cyclohexyl-2-crotonolactone[J]. Chinese Journal of Modern Applied Pharmacy, 2005, (1): 47-48.
Citation:
ZHANG Shi-ying, LIU Hong, WANG Jie, WU Da-jun. Synthesis of 3-[4-(methylsulfonyl)phenyl]-2-cyclohexyl-2-crotonolactone[J]. Chinese Journal of Modern Applied Pharmacy, 2005, (1): 47-48.
ZHANG Shi-ying, LIU Hong, WANG Jie, WU Da-jun. Synthesis of 3-[4-(methylsulfonyl)phenyl]-2-cyclohexyl-2-crotonolactone[J]. Chinese Journal of Modern Applied Pharmacy, 2005, (1): 47-48.
Citation:
ZHANG Shi-ying, LIU Hong, WANG Jie, WU Da-jun. Synthesis of 3-[4-(methylsulfonyl)phenyl]-2-cyclohexyl-2-crotonolactone[J]. Chinese Journal of Modern Applied Pharmacy, 2005, (1): 47-48.
Synthesis of 3-4-(methylsulfonyl)phenyl-2-cyclohexyl-2-crotonolactone
OBJECTIVE To modify the structure of Rofecoxib(COX-2 inhibitor) and synthesize the title compound.METHOD The title compound was synthesized from p-methylsulfonyl-acetophenone via bromination ,condensation and cyclization.RESULTS The total yield amount
DownLoad: