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    ZHANG Shi-ying, LIU Hong, WANG Jie, WU Da-jun. Synthesis of 3-4-(methylsulfonyl)phenyl-2-cyclohexyl-2-crotonolactoneJ. Chinese Journal of Modern Applied Pharmacy, 2005, (1): 47-48.
    Citation: ZHANG Shi-ying, LIU Hong, WANG Jie, WU Da-jun. Synthesis of 3-4-(methylsulfonyl)phenyl-2-cyclohexyl-2-crotonolactoneJ. Chinese Journal of Modern Applied Pharmacy, 2005, (1): 47-48.
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    Synthesis of 3-4-(methylsulfonyl)phenyl-2-cyclohexyl-2-crotonolactone

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    • OBJECTIVE To modify the structure of Rofecoxib(COX-2 inhibitor) and synthesize the title compound.METHOD The title compound was synthesized from p-methylsulfonyl-acetophenone via bromination ,condensation and cyclization.RESULTS The total yield amount
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