Study on the synthesis and bioactivity of N,N-bis-substituted urea derivatives as novel small molecular inhibitors of cysteine protease of Tryponosoma cruzi

GUO Chun; FANG Lin; Xiaohui Du; Fred E.Cohen

GUO Chun, FANG Lin, Xiaohui Du, Fred E.Cohen. Study on the synthesis and bioactivity of N,N-bis-substituted urea derivatives as novel small molecular inhibitors of cysteine protease of Tryponosoma cruzi[J]. Chinese Journal of Modern Applied Pharmacy, 2004, (5): 361-365.

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Study on the synthesis and bioactivity of N,N-bis-substituted urea derivatives as novel small molecular inhibitors of cysteine protease of Tryponosoma cruzi

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OBJECTIVE To search the small molecular inhibitors of cysteine protease of Tryponosoma cruzi.METHOD The N,N-bis-substituted urea was chosen as the lead scaffold based on the computational molecular modeling of cruzain. The target compounds were synthesi

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Study on the synthesis and bioactivity of N,N-bis-substituted urea derivatives as novel small molecular inhibitors of cysteine protease of Tryponosoma cruzi

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