Synthesis of nefiracetam

KUANG Chun-tao, HU Ai-xi, WANG Chun-lei, TANG Fei. Synthesis of nefiracetam[J]. Chinese Journal of Modern Applied Pharmacy, 2003, (6): 489-490.

Citation:

KUANG Chun-tao, HU Ai-xi, WANG Chun-lei, TANG Fei. Synthesis of nefiracetam[J]. Chinese Journal of Modern Applied Pharmacy, 2003, (6): 489-490.

Citation:

KUANG Chun-tao, HU Ai-xi, WANG Chun-lei, TANG Fei. Synthesis of nefiracetam[J]. Chinese Journal of Modern Applied Pharmacy, 2003, (6): 489-490.

Abstract

OBJECTIVE To synthesize nefiracetam. METHOD Nefiracetam was synthesized by N acylation of 2,6-dimethylbenzenamine with chloroacetylchloride and N-alkylation of 2-pyrrolidone.RESULTS The overall yield was 89.9%. The structure of nefiracetam was confirm

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