Synthesis of raloxifene hydrochloride

JIA Wei-ru, ZHANG Jing. Synthesis of raloxifene hydrochloride[J]. Chinese Journal of Modern Applied Pharmacy, 2003, (3): 184-185.

Citation:

JIA Wei-ru, ZHANG Jing. Synthesis of raloxifene hydrochloride[J]. Chinese Journal of Modern Applied Pharmacy, 2003, (3): 184-185.

Citation:

JIA Wei-ru, ZHANG Jing. Synthesis of raloxifene hydrochloride[J]. Chinese Journal of Modern Applied Pharmacy, 2003, (3): 184-185.

Abstract

OBJECTIVE To Synthesize Raloxifene Hydrochloride. METHOD Raloxifene was synthesized by cyclizing and demethoxylating of 3 methoxybenzenethiol, then treated with 4-2-(1-pyrroldinyl)ethoxybenzoyl chloride in the presence of monothioglycol to give Ralox

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