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    Xu Yungen(Xu YG), Luo Sui(Luo S), Hua Weiyi(Hua WY). Synthesis of sibutramine hydrochloride[J]. Chinese Journal of Modern Applied Pharmacy, 2000, (5): 380-381.
    Citation: Xu Yungen(Xu YG), Luo Sui(Luo S), Hua Weiyi(Hua WY). Synthesis of sibutramine hydrochloride[J]. Chinese Journal of Modern Applied Pharmacy, 2000, (5): 380-381.
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    Synthesis of sibutramine hydrochloride

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    • OBJECTIVE:To modify the synthetic method of sibutramine hydrochloride.METHOD:Sibutramine hydrochloride was synthesized from 4-chlorophenylacetonitrile by reactions of cycloalkylation,Grignard reaction,reduction,Eschweiler Clarke methylation and salifying
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