Guo Feng(Guo F), Huang Guangdou(Huang GD), Lei Xiaodong(Lei XD) et al, . Improved synthesis of dl-naproxen by carboxylation-alkylation[J]. Chinese Journal of Modern Applied Pharmacy, 1998, (2): 32-33.
Citation:
Guo Feng(Guo F), Huang Guangdou(Huang GD), Lei Xiaodong(Lei XD) et al, . Improved synthesis of dl-naproxen by carboxylation-alkylation[J]. Chinese Journal of Modern Applied Pharmacy, 1998, (2): 32-33.
Guo Feng(Guo F), Huang Guangdou(Huang GD), Lei Xiaodong(Lei XD) et al, . Improved synthesis of dl-naproxen by carboxylation-alkylation[J]. Chinese Journal of Modern Applied Pharmacy, 1998, (2): 32-33.
Citation:
Guo Feng(Guo F), Huang Guangdou(Huang GD), Lei Xiaodong(Lei XD) et al, . Improved synthesis of dl-naproxen by carboxylation-alkylation[J]. Chinese Journal of Modern Applied Pharmacy, 1998, (2): 32-33.
Improved synthesis of dl-naproxen by carboxylation-alkylation
dl-Naproxen was directly synthesized via reduction and hydrolysis of ethyl (5-bromo-6-methoxy-2-naphthyl )-a -methyl acetate (2), which was prepared by Friedel-Crafts reaction with 1-bromo-2methoxynaphthalene and ethyl 0-(p-methyl benzene sulfonyl) lactat
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