Improved Synthesis of 19-Norehisterone Acetate
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Graphical Abstract
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Abstract
19-Norethisterone acetate is prepared by heating 19-norethisterone with Ac2O. It was wise to add NaAc in the operation of steaming distillation, to let it become a buffer pair with HAc and to prevent 19-norethis-terone acetate from hydrolyzing. The struct
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