Effects of Drugs on Antigen-induced Bronchoconstrictor and AirwayMicrovascular Leakage in Sensitized Guinea Pigs

In actively sensitized guinea pigs, ONO-1078, a potent spesific antagonist forleukotrienes, inhibited the antigen-induced microvascular leakage in the bronchi, lungs andbrochoconstrictor response. Metyrapone poteatiated these responses, while hydrocortiso