Silicon Dioxide used as Antistatic Agents in Powder Preparation

OBJECTIVE To investigate Aerosil(silicon dioxide) used as antistatic agents in powder granulation by fluid bed. METHODS The electrostatic phenomena will happen and affect the process of granulation seriously in powder granulation by fluid bed. To solve the problem, we used PVC powder as the model drug. The change of powder electrostatic potential and electrical surface resistivity with the addition of Aerosil was measured by contact electrostatic probe method. RESULTS The static electricity and the surface resistance was significantly lowered, and the powder electrostatic adsorption was disappeared when the Aerosil in 0.8% mass fraction. CONCLUSION The static electricity is eliminated obviously by using the Aerosil which is significant to the granule making by fluid bed.