Preventive and Therapeutic Effects of Semen Cassiae Hawthorn Oat Capsules on Fatty Liver in Rats

OBJECTIVE To study the preventive and therapeutic effects of Semen Cassiae Hawthorn Oat capsules on fatty liver in rats. METHODS Fatty liver model of rat was established by feeding high fat diet. By measuring the general physical state, contents of serum total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), alanine transaminase (ALT), aspartate transaminase (AST), superoxide disutase (SOD), malondiadehyde (MDA) and hepatic pathological changes in rats, the protective effect of Semen Cassiae Hawthorn Oat capsules were evaluated. RESULTS Compared with fatty liver model group, Semen Cassiae Hawthorn Oat capsules could significantly lower the contents of TC and TG (P<0.01), significantly increase the contents of the HDL-C(P<0.05), significantly lower the contents of MDA, ALT and AST in sera (P<0.05), obviously ameliorate hepatic pathological changes and lighten hepatic steatosis of fatty liver rats in treated groups. CONCLUSION Semen Cassiae Hawthorn Oat capsules have effects of regulating the blood lipids and preventing and treating fatty liver in rats.