Effects of Puerarin on Lipidemia, Blood Coagulation and Platelet Aggregation in Hyperlipidemia Rats

OBJECTIVE To explore effects of puerarin on lipidemia, blood coagulation and platelet aggregation in experimental hyperlipidemia rats. METHODS Experimental hyperlipidemia rats were ip administration of puerarin (50 mg·kg^-1·d^-1) or vehicle (0.9% NaCl) in 30 d. The levels of plasma triplyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), malondialdehyde (MDA), superoxide dismutase (SOD), prothrombin time (PT), activated partial thrombplastin time (APTT), and platelet maximal aggregation rate(MAR) which was induced by ADP in 5 min were measured. RESULTS Plasma TG, TC, LDL-C and HDL-C of the rats fed high fat diet (HFD) and ip puerarin (50 mg·kg^-1·d^-1) were 27%, 21%, 39% lower and 24% higher than that of HFD group rats. The PT and APTT of puerarin and HFD group rats were significantly longer than that of the HFD group (P<0.05). The SOD in puerarin and HFD group was higher (P<0.05) and the MDA and MAR in puerarin and HFD group was lower than that of HFD group (P<0.01). CONCLUSION Puerarin can reduce the serum lipid level of the hyperlipidemia rats effectively and prevent the lipid peroxidation, moreover blood clotting system in hyperlipidemia rats is improved effectively.