Effect of Losartan on Blood Pressure Variability and Brachial-ankle Pulse Wave Velocity in Essential Hypertensive Patients Complicated with Type 2 Diabetes Mellitus

OBJECTIVE To investigate the effect of losartan on blood pressure variability(BPV) and brachial-ankle pulse wave velocity (baPWV) in essential hypertensive (EH) patients complicated with type 2 diabetes mellitus (DM). METHODS Sixty patients with EH and DM took losartan (100-200 mg·d^-1) orally for 24 weeks(treatment group). The changes of BPV and baPWV were analyzed and compared with that of normal control group (n=58). RESULTS The BPV and baPWV of patients with EH and DM in treatment group were significantly higher than that of normal control group. After losartan treatment(24 weeks), the BPV and baPWV were significantly lower than that of the normal control group. CONCLUSION Losartan can decrease blood pressure and improve BPV, and better blood vessel stiffness.