Synthesis and Antibacterical Activity of Novel Macrocyclic Schiff Base Compounds Containing 2-Substituted-1,3-dithiolane

OBJECTIVE To exploit a novel antibacterical agent. METHODS A series of macrocyclic Schiff base compounds containing 2-substituted-1,3-dithiolane were synthesized from different β-diketonato, carbon disolfide and 1,2-dibromoethane. Their antibacterial activities were tested. RESULTS The structure and composition of the middle compounds(Ⅰa-Ⅰc) and title Schiff base compounds(Ⅱa-Ⅱc) were elucidated on the basis of elemental analysis, IR, 1H-NMR, and MS. The title Schiff base compounds proved a better antibacterial activity. CONCLUSION The title Schiff base compounds(Ⅱa-Ⅱc) are synthesized, and they show good antibacterial activity.