Optimization of the Preparation Process of Complex Prescription Yungui Granules

OBJECTIVE To optimize preparation technology of complex prescription Yungui granules(CPYGG). METHODS Using the content of ferulaic acid in Ligustici Radix and naringin in Aurantii Fructus as the index, HPLC was used to quantitative, extraction time, the amout of water, extracting times, degree on extraction technology were evaluated by L9(34) orthogonal design method. Granulating conditions were studied. RESULTS The superior technology of water extraction were as follows: 10 times as much water, extracted 1.5 h for 2 times. Wetting agent was 90% alcohol, extraction powder∶ adjuvant was 1∶0.5, 0.2% sweeting agent was added. CONCLUSION The preparation procedure is stable and feasible, it can be used for the preparation of CPYGG.