QI Haofei, WANG Bing, LIU Bingni, LIU Mo, LIU Dengke. Synthesis of Pazopanib Hydrochloride[J]. Chinese Journal of Modern Applied Pharmacy, 2011, 28(1): 58-60.
Citation:
QI Haofei, WANG Bing, LIU Bingni, LIU Mo, LIU Dengke. Synthesis of Pazopanib Hydrochloride[J]. Chinese Journal of Modern Applied Pharmacy, 2011, 28(1): 58-60.
QI Haofei, WANG Bing, LIU Bingni, LIU Mo, LIU Dengke. Synthesis of Pazopanib Hydrochloride[J]. Chinese Journal of Modern Applied Pharmacy, 2011, 28(1): 58-60.
Citation:
QI Haofei, WANG Bing, LIU Bingni, LIU Mo, LIU Dengke. Synthesis of Pazopanib Hydrochloride[J]. Chinese Journal of Modern Applied Pharmacy, 2011, 28(1): 58-60.
OBJECTIVE To synthesis pazopanib hydrochloride and optimize the process. METHODS Pazopanib hydrochloride was synthesized from 3-methyl-6-nitro-1H-indazole via N-methylation, reduction, nucleophilic substitution and salification. RESULTS Chemical structure of pazopanib hydrochloride was confirmed by 1H-NMR, MS and IR. CONCLUSION The method is suitable for industry.
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