Practical Synthesis of 3-Chloro-4-(3-fluorobenzyloxy) aniline

OBJECTIVE To develop a practical process for 3-chloro-4-(3-fluorobenzyloxy)aniline. METHODS 3-Chloro- 4-(3-fluorobenzyloxy)aniline was synthesized from 1-(chloromethyl)-3-fluorobenzene and 2-chloro-4-nitrophenol via condensation in the presence of potassium carbonate, followed by reduction with Fe/NH4Cl. RESULTS The overall yield of this process was 82%. The target product was characterized by TLC, melting point and 1H-NMR. CONCLUSION This synthetic process features are cheap and readily available starting materials, robustness, less waste burden, thus should be amenable to industrial production.