UV Fiber-optical Process Monitoring for Dissolution Behavior of 5 Solid Dosage Forms of Cefixime

OBJECTIVE To develop an UV fiber-optical process monitoring method for dissolution behavior of five solid dosage forms of cefixime. METHODS Using the six channel fiber optical chemical sensor linked with-dissolving apparatus the dissolution rate of cefixime dispersible tablets was monitored by dynamic multiplying factor to eliminate interference of excipient. RESULTS The dissolution results measured by the instrument have no significant difference compared with the USP30-NF25. CONCLUSION The method needs no sampling and dilution. It can monitor the drug dissolution real-time.