Palladium Residues Determination in Valaciclovir Hydrochloride by Graphite Furnace Atomic Absorption Spectrometry

OBJECTIVE To establish a method for the determination of Pd in valaciclovir hydrochloride. METHODS Appling microwave degrading system to deteriorate sample, use a graphite furnace atomic absorption spectrometry (AAS) method to determine Pd residues in valaciclovir hydrochloride. RESULTS It showed a good linear relationship within the concentration range of 1.0-30.0 μg·L^-1(r=0.999 5). The LOD and LOQ were 0.20 μg·L^-1 and 0.95 μg·L^-1, respectively. The characteristic concentration (sensitivity) was 0.57 μg·L^-1 and the average recovery was 101.69%. CONCLUSION This method is sensitive, accurate and reliable to control the residues of Pd in valaciclovir hydrochloride, providing the basis for drug quality control.