Study on Dissolution Test of Meleumycin Capsules

OBJECTIVE To establish a method for the determination of dissolution of meleumycin capsules. METHODS The dissolution of meleumycin capsules was determined by UV spectrophotometry at 235 nm，using 900 mL hydrochloric acid solution(24 mL hydrochloric acid test solution was dilluted to 1 000 mL with water) containing 1% pepsin as the medium. The rotation speed was 100 r·min^-1 and the sampling time was 45 min. RESULTS The method showed a good linear relationship in the range of 5.06-30.35 μg·mL^-1(r=0.999 2). The average recoveries were 100.09%(RSD=1.1%) and 99.61%(RSD=1.2%) for two different types of samples, respectively. The dissolutions of 6 batches of samples were all above 80%. CONCLUSION The method is accurate and reliable, and it can be applied for the determination of the dissolution of meleumycin capsules.