Affects on Cyclooxygenase Activities and Anti-inflammations Effects of Tetra-acetylated Puerarin

OBJECTIVE To investigate anti-inflammatory effects and cyclooxygenase-inhibitory effects of tetra-acetylated puerarin. METHODS The anti-inflammatory effect of tetra-acetylated puerarin was observed by using the rat inflammation model induced by Carrageenan, and the cyclooxygenase activity of tetra-acetylated puerarin was observed by radioimmunoassay(RIA). RESULTS Tetra-acetylated puerarin (40 mg·kg^-1) can significantly decrease the rat paw edema for the inhibition effects on foot edema. Compared with indomethacin, the effect on COX-2 of puerarin derivatives showed no significant difference(P>0.05). And the 50% inhibitory concentration (IC_{50-1. CONCLUSION Tetra-acetylated puerarin has significant anti-inflammatory activity and selective inhibition effect on the COX-2, and it has a good application prospects.}