Evaluation of the Release Rate of Gossypol Acetate from a Gossypol-Loaded Intrauterine Device in Mice

OBJECTIVE To explore the release rate of gossypol acetate from a designed gossypol-loaded intrauterine device (IUD) in mice. METHODS The mice were administrated with gossypol acetate-loaded IUD and then the release rate of gossypol acetate from the IUD was tested by HPLC. RESULTS The results showed that the concentration of plasma gossypol acetate gradually increased to a peak level of 0.30 μg·L^-1 on the second day, which was then maintained for several months. CONCLUSION A gossypol-loaded IUD is a reliable method of administration for gossypol acetate and it is possibly an effective way to treat adenomyosis in mice.