Impurity Profile Study of Cefmenoxime Hydrochloride for Injection

OBJECTIVE To establish an UHPLC-TOF-MS method for the research of the impurity profile of cefmenoxime hydrochloride for injection. METHODS UHPLC-TOF-MS was used with Waters UPLC HSS T3 column(2.1 mm×100 mm, 1.8 μm). The mobile phase consisted of 0.1% formic acid(A) and acetonitrile(B) with gradient program. The column temperature was 40 ℃. The flow rate was 0.3 mL·min^-1. RESULTS There were 15 related substances detected in the sample, all of which were identified. CONCLUSION The UHPLC-TOF-MS method can be used for the related substances study of cefmenoxime hydrochloride for injection.