Quantitative Detection and Analysis of Norfloxacin: An Electrochemical Method Based on Conductive Diamond Electrode

OBJECTIVE To analyze the electrochemical behavior of norfloxacin and achieve its quantitative detection by using boron-nitrogen co-doped diamond(BNDD) electrode.

METHODS The electrochemical behaviors of norfloxacin were examined by cyclic voltammetry(CV) and differential square wave voltammetry(SWV) in a three-electrode system with a BNDD electrode as the working electrode.

RESULTS In standard buffer solution(pH=6.5), the oxidation peak currents(I_p) of the norfloxacin response increased significantly with the increase of concentration, showing a linear relationship in the range of 0.1 to10 μmol·L^–1, with the low detection limit of 0.036 μmol·L^–1. The established method showed good stability, repeatability and anti-interference ability.

CONCLUSION The BNDD electrode features high electrochemical detection sensitivity and outstanding comprehensive performance, and is suitable for efficient and rapid monitoring of norfloxacin in clinical pharmaceutical fields.