Determination Method of Radioactivity of Radiopharmaceuticals Labeled with Lutetium ¹⁷⁷Lu Nuclide

OBJECTIVE  To establish a method for the determination of radioactivity of radiopharmaceuticals labeled with lutetium ¹⁷⁷Lu nuclide.

METHODS  The radioactivity was determined by high-purity germanium gamma spectrometer(HPGe), liquid scintillation counting(LSC), and radioactivity meter method.

RESULTS  Three methods based on different principles for the determination of radioactivity were established, the linear relationships were good within the range of radioactivity determination by different instruments(r=1.0), and the determination results were relatively consistent after normalization of the determination time.

CONCLUSION  The established analytical method for lutetium ¹⁷⁷Lu nuclide labeled radiopharmaceuticals is highly operable and accurate, and can be used for the quality analysis and control of radiopharmaceuticals labeled with this nuclide.