Study on Pharmacokinetic Behavior of Scutellarin Base on Solubilization Effect of Deep Eutectic Solvents

OBJECTIVE  To study the solubilization effect of different types of deep eutectic solvents(DESs) on scutellarin and its pharmacokinetic behavior after oral administration in rats.

METHODS  An HPLC method was established to determine the solubility of scutellarin in different DESs. Scutellarin solutions were prepared with water and different DESs, and rats were given different scutellarin solutions by gavage. The pharmacokinetics of scutellarin solutions were studied by plasma drug concentration-time curve and pharmacokinetic parameters.

RESULTS  The solubility of DESs to scutellarin was much higher than that of traditional solvents, and the solubility was the highest in choline chloride/ethylene glycol. The pharmacokinetic study showed that the area under the drug concentration-time curve of the DESs group was significantly increased compared with the water suspension group, and prolonged the residence time of scutellarin in the blood.

CONCLUSION  DESs have a strong solubilization effect on scutellarin, and the oral bioavailability of scutellarin is significantly enhanced by DESs.