Comprehensive Clinical Evaluation of Amphotericin B in the Treatment of Invasive Fungal Disease

OBJECTIVE  To explore the establishment of a clinical comprehensive evaluation index system for the treatment of invasive fungal infections and to conduct empirical research, aiming to provide methodological references for rational clinical use in hospitals.

METHODS  Based on literature review and relevant guidelines, the Delphi method was used to construct a clinical comprehensive evaluation index system and evaluation criteria for the treatment of invasive fungal infections. Empirical research was conducted using amphotericin B deoxycholate(AmBd), liposomal amphotericin B(L-AmB), and amphotericin B colloidal dispersion(ABCD) as examples.

RESULTS  After expert validation, six primary indicators and thirteen secondary indicators were finalized along with their corresponding weights and quantitative scoring. According to the collected evidence, the clinical comprehensive value scores of ABCD, L-AmB and AmBd were 73.50, 70.50 and 49.50, respectively.

CONCLUSION  Empirical research indicates that the clinical comprehensive value score of ABCD is higher than that of L-AmB and AmBd. The clinical comprehensive evaluation index system and evaluation criteria for the treatment of invasive fungal infections can provide reference for rational drug use in clinical practice.